Beyond glycemic control: semaglutide's multifaceted impact on metabolic health

Parveen, Shaik and Boddu, Ajay and Narala, Sharanya (2025) Beyond glycemic control: semaglutide's multifaceted impact on metabolic health. International Journal of Science and Research Archive, 14 (2). pp. 1626-1634. ISSN 2582-8185

Achieving ideal glycemic control is essential for those with Type 2 Diabetes Mellitus (T2DM), as is avoiding hypoglycemia, controlling body weight, and lowering cardiovascular risk. A prospective treatment strategy that meets these demands is provided by agonists of the Glucagon-Like Peptide-1 receptor. These drugs block glucagon secretion, slow stomach emptying, decrease appetite, and increase glucose-dependent insulin secretion, all of which help control weight and minimize the risk of hypoglycemic episodes. Furthermore, a number of GLP-1 receptor agonists have shown promising increase in renal and cardiovascular health. Patients might have a more convenient treatment regimen because they are accessible as weekly or daily injections. Furthermore, a lower risk of cardiovascular disease has been associated with some GLP-1 receptor agonists. According to recent studies, these substances may also have a number of neuroprotective advantages, such as increasing neurogenesis, lowering cell death, shielding neurons from oxidative stress, and lowering neuroinflammation in a range of neurological disorders. These substances are therefore being investigated as potential therapies for neurodegenerative illnesses like Parkinson's and Alzheimer's.