Beyond the hype: A critical review of crispr-Cas9 gene editing therapies

Shaik, Farheen Taj and Yarra, Sravani (2025) Beyond the hype: A critical review of crispr-Cas9 gene editing therapies. International Journal of Science and Research Archive, 14 (2). pp. 1525-1539. ISSN 2582-8185

CRISPR-Cas9 gene editing has emerged as a revolutionary tool with the potential to reshape medicine. However, critical evaluation is necessary to navigate beyond the hype and assess its true therapeutic potential. This review examines the background, promise, and challenges of CRISPR-Cas9 therapies. It explores its simplicity, efficiency, and transformative impact on biological research. While acknowledging the excitement, the review emphasizes the need to address ethical concerns, off-target effects, delivery issues, and long-term safety. By critically appraising the efficacy, safety, and ethical considerations, this review aims to inform stakeholders about the realities of implementing CRISPR-Cas9 in clinical practice. Furthermore, it explores future directions in research and emphasizes the importance of responsible development and implementation to maximize benefits while minimizing risks.