The effect of administering synthetic protein signal transducers and activators transcription 5a on total leukocytes, leukocyte differentials and erythrocyte indices on broilers is significant

Damayanti, Ratna and Ma’ruf, Anwar and Yuliani, M. Gandul Atik and Santoso, Kuncoro Puguh and Salsabilla, Azzahra Nourish and Nugroho, Muhammad Zuhdianto and Triakoso, Nusdianto and Dhamayanti, Yeni and Mufasirin, Mufasirin and Supriyadi, Supriyadi (2025) The effect of administering synthetic protein signal transducers and activators transcription 5a on total leukocytes, leukocyte differentials and erythrocyte indices on broilers is significant. World Journal of Advanced Research and Reviews, 25 (2). pp. 1847-1857. ISSN 2581-9615

Chicken meat itself has a high nutritional content of protein and energy. STAT5a is an important protein in the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signal pathway. This is particularly relevant given the growing global market demand for healthy, safe, and antibiotic-free chicken meat. By understanding how STAT5a affects total leukocytes, differential leukocytes, and erythrocyte indices this study is expected to make an important contribution in developing new strategies to improve the health and productivity of broiler chickens. This study was an experimental study using a complete randomized design with The Post-test Only Control Group Design which consisted of five experimental groups (treatments) using broiler chicken as a test animal. The administration of the synthetic protein STAT 5a can increase the total blood leukocytes of broiler chickens, but still within normal limits. The administration of the synthetic protein STAT 5a can increase the heterophyil of broiler chickens, but still within normal limits. The administration of the synthetic protein STAT 5a can increase broiler chicken lymphocytes, but still within normal limits. The administration of the synthetic protein STAT 5a can increase the monocyte of broiler chickens, but still within normal limits. The administration of STAT-5a proteins at doses of 3.5%, 7% and 14% increased the Mean Corpuscular Volume (MCV) value and the dose of 3.5% was optimal. The administration of the 3.5% dose of STAT-5a protein increases the mean corpuscular hemoglobin (MCH) value and is the optimal dose. The administration of the 3.5% dose of STAT-5a protein increases the mean corpuscular hemoglobin concentration (MCHC) value and is the optimal dose.