Atypical posterior reversible encephalopathy syndrome presenting with cortical laminar necrosis: A case report

Essolaymany, Zineb and Ezzoulali, Zineb and Ouazzani, Hajar and Chaouche, Ismail and Akammar, Amal and Bouardi, Nizar El and Alami, Badreddine and Bouchal, Siham and Chtaou, Chtaou and Belahsen, Faouzi and Boubbou, Meryem and Maâroufi, Mustapha and Lamrani, Moulay Youssef Alaoui (2025) Atypical posterior reversible encephalopathy syndrome presenting with cortical laminar necrosis: A case report. World Journal of Advanced Research and Reviews, 27 (2). pp. 224-230. ISSN 2581-9615

Posterior reversible encephalopathy syndrome (PRES) represents a neurological disorder with varied clinical presentation and typical imaging findings of predominant vasogenic edema in the parieto-occipital regions. The imaging abnormalities found in PRES are usually reversible. In some rare cases, it can lead to irreversible damage to the cerebral parenchyma, leading to cortical laminar necrosis, which is an atypical feature of PRES. We describe a unique case of a patient admitted for an atypical PRES presenting with generalized tonic-clonic seizures and imaging features of cortical laminar necrosis. To our knowledge, our case is only the third one reported of PRES carrying imaging features of cortical laminar necrosis.