Genetics behind violent behavior

Hernandez, Regina and Félix, Aleli Y and Fernández, Esaú N and Quiñonez, Yara C and Bautista, Manuel A and Lazalde, Brissia (2025) Genetics behind violent behavior. GSC Advanced Research and Reviews, 32 (3). pp. 181-186. ISSN 2582-4597

The aim of this article is to provide a review of the influence of genetic factors on aggressive behaviour. A variety of factors, including impulsivity, aggression, and rule-breaking, are complex traits influenced by both genetic predispositions and environmental exposures. Recent research has focused on gene-gene interactions, particularly between the serotonin transporter-linked polymorphic region (5-HTTLPR) and the dopamine D4 receptor (DRD4) gene variants, as key modulators of such behaviors. The extant literature suggests that the presence of the DRD4 7-repeat (7r) allele alters the effect of 5-HTTLPR on externalizing behavior, indicating an epistatic interaction that may contribute to individual differences in behavioral responses. These findings support the notion that genetic variants do not act in isolation but interact to influence the risk of developing violent and impulsive behaviors. Comprehension of these intricate genetic relationships is imperative for the identification of individuals with elevated risk. This understanding offers potential avenues for the development of personalized prevention and treatment approaches for behavioral disorders. Further studies are needed to explore the mechanisms underlying these interactions and their interplay with environmental factors.