The silent revolution in drug delivery: Exploring the extraordinary potential of nanosponges in modern medicine

Jalli, Maheshbabu and Kumar D, Vinay and Supriya P, Satya Hima and Rajeswari M, Uma and Sai S, Jithendra Lakshman (2025) The silent revolution in drug delivery: Exploring the extraordinary potential of nanosponges in modern medicine. GSC Biological and Pharmaceutical Sciences, 31 (3). pp. 317-329. ISSN 2581-3250

Nanosponges are a new class of smart drug carriers with great promise in improving drug delivery. These tiny, sponge-like particles are made by crosslinking polymers such as cyclodextrins, creating a porous structure that can hold a variety of drugs. Because of their unique design, nanosponges can carry water-soluble and fat-soluble drugs, protect sensitive drugs from breaking down, and release them slowly over time. They are stable across a wide pH and temperature range, and they reduce side effects by targeting drugs to specific sites in the body. Multiple preparation methods, including ultrasound-assisted, microwave-based, and solvent techniques, offer flexibility in design and performance. Their effectiveness is evaluated using particle size analysis, zeta potential, and spectroscopy. Applications of nanosponges include cancer therapy, antifungal treatments, protein delivery, and detoxification. Their ability to improve solubility, reduce toxicity, and allow for sustained release makes them a valuable tool in modern pharmaceutical science.