Urinary tract infection and damage caused by Escherichia coli Uropathogenic factors

radef, Wafaa Tali and Musa, Farkad Hawas and Khalaf, Ibtehal Mohammed (2025) Urinary tract infection and damage caused by Escherichia coli Uropathogenic factors. GSC Biological and Pharmaceutical Sciences, 31 (3). pp. 310-316. ISSN 2581-3250

The vast majority of UTIs in healthy people and in patients transplanted by kidney transplants are caused by UP Esherichia coli, including cystitis and pyelonephritis, and complicated infectious disease, which can lead to an acute renally failure (UPEC). A variety of virulence factors are expressed in the UPEC to break down mucosal barrier inertia. Cytokine synthesis, the neutrophil infection inflow as well as the part of the inflammatory HOST responses to the UPEC urinary tract. During UPEC infection, several signals interact with calcium-dependent signaling pathway, including routes causing natural immune reactions. However, such UPEC isolates could have strategies to postpone the host response elements in the urinary tract or to inhibit them. New information on how uropathologic E. coli virulence factors trigger the innate host response is obtained from recent studies. UPEC can live in the urinary tract in spite of many host defense mechanisms and function as a reservoir for chronic diseases and serious complications. In order to develop successful strategies to prevent human UTIs and urologically related UTIs, it is important to provide molecular data on these cases.