Phytochemical screening, In-vitro Wound healing, Antifungal and Antimicrobial activity of Leucas aspera and Leucas indica

Swapna, Kota.Venkata and Lakshmi, Ankala.Guru and Sowmya, Gudimallam.Sai and bai, Kande.Himabindu and Aswani, Kotakonda. and Keerthi, Kokati. (2025) Phytochemical screening, In-vitro Wound healing, Antifungal and Antimicrobial activity of Leucas aspera and Leucas indica. GSC Biological and Pharmaceutical Sciences, 31 (1). 001-009. ISSN 2581-3250

Leucas aspera commonly known as Thumbai is distributed throughout India from the Himalayas down to ceylon. The plant is used traditionally as an antipyretic and insecticide. Medicinally, it has been proven to possess various pharmacological actions like anti-fungal, antioxidant, antimicrobial, and cytotoxic activity. Further studies reveal the presence of various phytochemical constituents mainly triterpenoids, nicotine, sterols, glucoside, diterpenes, phenolic compounds (4-(24-hydroxy-1-oxo-5-propyltetracosanyl)-phenol). These studies reveal that Leucas aspera is a source of medicinally active compounds and have various pharmacological effects; hence this drug encourage finding its new therapeutic uses. Leucas indica belongs to the family Lamiaceae also known as Guma, Tumba, Dandokalos. Traditionally it is a Garhwal region of Uttarakhand as a wound healer. The leaf of this plant are squeezed and placed on wounds to acquire wound healing. Leaves are also used as vermifuge, stomachic, sedation and in sores.A new phenylethanoid glycoside 2-(3,4-dihydroxyphenyl)-ethyl-0-L-rhamnopyranosyl-(1--3)-0-A-rhamnopyranosyl-(1--6)-4-0-E-feruloyl-B-D-glucopyranoside(3-0-methyl poliumoside,1)along with five known phenylethanoid glycosides (2-6)were isolated from the aerial parts of Leucas indica linn. The structure of component 1 has been elucidated on the basis of spectral data.