Neurological Manifestations of COVID-19: A review of the impact on chronic neurological conditions

Khansole, Nagesh G. and Barewar, Supriya S. and Bakal, Ravindra L. and Hatwar, Pooja R. (2025) Neurological Manifestations of COVID-19: A review of the impact on chronic neurological conditions. GSC Biological and Pharmaceutical Sciences, 30 (3). pp. 298-310. ISSN 2581-3250

Coronavirus disease 2019 (COVID-19) is a global pandemic caused by SARS-CoV-2 infection and is associated with both acute and chronic disorders affecting the nervous system. This comprehensive review aims to summarize the current knowledge on the impact of COVID-19 on the nervous system, including epilepsy, Parkinson's disease, Alzheimer's disease, multiple sclerosis, ischemic stroke, and Guillain-Barré syndrome. The review highlights the increased risk of neurological complications in patients with pre-existing neurological conditions, such as epilepsy, Parkinson's disease, and multiple sclerosis. Additionally, COVID-19 infection has been linked to a range of neurological symptoms, including headaches, seizures, encephalitis, and stroke. The pathophysiology of COVID-19-related neurological manifestations is complex and multifactorial, involving direct viral invasion, immune-mediated mechanisms, and systemic inflammation. The review discusses the potential therapeutic strategies for managing COVID-19-related neurological complications, including antiviral medications, immunomodulatory therapies, and supportive care. The review also emphasizes the importance of telemedicine and remote monitoring in managing patients with chronic neurological conditions during the COVID-19 pandemic. Furthermore, it highlights the need for ongoing research to better understand the long-term neurological consequences of COVID-19 infection and to develop effective strategies for prevention and treatment.