Verification of the analytical performance of the serum Beta-2 microglobulin (β2M) assay on the Abbott Alinity ci®: Experience of the Biochemistry Laboratory of the Mohammed VI University Hospital, Oujda

Kharkhach, Oumaima and Jamal, Kaoutar and Elmoujtahide, Dounia and Sebbar, El Houcine and Choukri, Mohammed (2025) Verification of the analytical performance of the serum Beta-2 microglobulin (β2M) assay on the Abbott Alinity ci®: Experience of the Biochemistry Laboratory of the Mohammed VI University Hospital, Oujda. GSC Biological and Pharmaceutical Sciences, 30 (3). pp. 280-285. ISSN 2581-3250

The verification of analytical performance is a critical step in ensuring the reliability and accuracy of laboratory assays. This study aims to evaluate the analytical performance of the beta-2 microglobulin (β2M) immunoassay on the Abbott Alinity ci® platform in the central laboratory of Mohammed VI University Hospital of Oujda over a 30-day duration. The study assesses key analytical parameters, including precision, reproducibility, and repeatability against established standards, based on ISO 15189 accreditation guidelines. Results show low coefficients of variation (CV), with reproducibility ranging from 2.36% to 2.94% and repeatability from 1.00%to 2.55%, meeting the stringent criteria set by recognized professional societies. These findings confirm the robustness and reliability of the method and validate the analytical performance of the β2M assay, underscoring its suitability for clinical use.