Verification of the analytical performance of BNP (Brain Natriuretic Peptide) Assay on the Abbott Alinity ci®: Experience of the Biochemistry laboratory of Mohammed VI University Hospital in Oujda/Morocco

Faiz, Ismail and Rhoubi, Asmae and Moujtahide, Dounia El and Sebbar, El Houcine and Choukri, Mohammed (2025) Verification of the analytical performance of BNP (Brain Natriuretic Peptide) Assay on the Abbott Alinity ci®: Experience of the Biochemistry laboratory of Mohammed VI University Hospital in Oujda/Morocco. GSC Biological and Pharmaceutical Sciences, 30 (3). 071-076. ISSN 2581-3250

Brain Natriuretic Peptide (BNP) is a good cardiac biomarker used for diagnostic, prognostic, and therapeutic monitoring in heart failure, but also in other affections like pulmonary arterial hypertension (PAH). The purpose of our work is to evaluate the analytical performance of the BNP assay on the Abbott Alinity ci® Analyzer at the Biochemistry laboratory of the Mohammed VI University Hospital in Oujda. The methodology of this work is based on the evaluation of reproducibility and repeatability, based on the technical accreditation guide (SH GTA 04) of the French Accreditation Committee (COFRAC). The results obtained for the different BNP dosage verification criteria show satisfactory repeatability for all levels (1: low / 2: medium, and 3: high), Intra-laboratory reproducibility was also satisfactory for all levels. By comparing these results with the CV used by the CLSI, we see that the results are consistent with and below the tolerated limits. This study shows that the Biochemistry laboratory of the Mohammed VI University Hospital in Oujda can provide accurate and precise results which regards with the requirements of learned societies for the determination of BNP.