Characterization of nano encapsulated cinnamon bark extract (Cinnamomum burmannii) based on chitosan alginate as a potential drug delivery system for cervical cancer therapy

Susilowati, Aprilia and Herupradoto, Eduardus Bimo Aksono and Luqman, Epy Muhammad and Kasman, A. A. Muhammad Nur and Budiarto, Budiarto (2025) Characterization of nano encapsulated cinnamon bark extract (Cinnamomum burmannii) based on chitosan alginate as a potential drug delivery system for cervical cancer therapy. GSC Biological and Pharmaceutical Sciences, 30 (2). pp. 135-141. ISSN 2581-3250

Objective: This study aims to evaluate the nanoencapsulation potential of cinnamon extract based on the results of characterization tests. Method: Formulation F2 using a combination of 1% chitosan and 1.5% alginate showed optimal characterization results compared to F1 and F3. Results: The results showed that formulation F2 had a particle size of 246.3 nm, PDI of 0.396, and zeta potential of -33.8 mV indicating good physical stability, homogeneous particle distribution, and suitable particle size for nanoencapsulation applications. In addition, particle visualization showed clear and uniform physical properties, while a pH test of 7.32 supported suitability for oral delivery. Conclusion: Based on these characterization results, nanoencapsulation of cinnamon bark extract using chitosan alginate polymer shows significant potential as a drug delivery system for cervical cancer therapy