Nanoparticles: A promising approach for enhancing drug delivery and efficacy

Ajmire, Om N. and Hatwar, Pooja R. and Bakal, Ravindra L. and Thak, Ishar K. (2025) Nanoparticles: A promising approach for enhancing drug delivery and efficacy. GSC Biological and Pharmaceutical Sciences, 30 (2). pp. 117-126. ISSN 2581-3250

Nanoparticles (NPs) have emerged as a promising tool for enhancing drug delivery and efficacy with their unique properties, such as small size, high surface area, and biocompatibility, NPs can improve the solubility, permeability, and targeting of drugs. NPs can be synthesized from various materials, including natural or synthetic polymers, lipids, and metals. They offer several advantages, including improved bioavailability, targeted delivery, and reduced toxicity. This review article provides an overview of the types of NPs, their fabrication methods, and their applications in various drug delivery systems, including pulmonary, brain, topical, nasal, and ocular drug delivery. They can be used to treat respiratory diseases, neurological disorders, and cancers. However, there are challenges associated with NP-based drug delivery, including scalable and reproducible manufacturing, safety, and quality control.