Laughter-induced situational syncope: A rare and overlooked cause of transient loss of consciousness

Rehman, Abdul and Rehman, Saeed UR and Khan, Muhammad Yahya and Hameed, Raja Ansar (2025) Laughter-induced situational syncope: A rare and overlooked cause of transient loss of consciousness. World Journal of Advanced Research and Reviews, 27 (1). pp. 548-550. ISSN 2581-9615

Situational syncope is a subset of neurally mediated syncope triggered by specific physical activities or emotional responses. Among these, laughter-induced syncope is exceedingly rare and under recognized. We present the case of a 55-year-old male who experienced a transient loss of consciousness following a laughing episode at work place. Comprehensive cardiac and neurological evaluations were unremarkable, and the diagnosis was confirmed through tilt-table testing. This case emphasizes the importance of detailed clinical history and the utility of autonomic testing in diagnosing situational syncope.