Congenital Megalocornea, Microspherophakia, and Lens Subluxation Leading to Secondary Glaucoma in an Infant: A Case of Suspected LTBP2 Mutation

Daghouj, Ghizlane and Ennaki, Sara and ElKettani, Asmaa and Laftimi, Zyad and Maaloum, Loubna El and Allali, Bouchra (2025) Congenital Megalocornea, Microspherophakia, and Lens Subluxation Leading to Secondary Glaucoma in an Infant: A Case of Suspected LTBP2 Mutation. World Journal of Advanced Research and Reviews, 27 (1). pp. 378-381. ISSN 2581-9615

We report the case of a 6-month-old infant with congenital megalocornea, microspherophakia, and bilateral lens subluxation, leading to secondary glaucoma. Genetic context included consanguinity, suggesting an LTBP2-related condition. The patient underwent bilateral lensectomy with anterior vitrectomy, combined with trabeculectomy and peripheral iridectomy in the right eye. Postoperative intraocular pressure normalized in both eyes. This rare entity should be distinguished from primary congenital glaucoma, as the surgical approach differs. Regular intraocular pressure monitoring is essential in children with megalocornea and lens anomalies to ensure early detection and treatment of secondary glaucoma.