Study of the anesthetic activity of Novocaine-containing metal complexes

Metreveli, Lela Alexandre and Gvidani, Sophia Anzor and Bukia, Tinatin Jemal and Kakabadze, Manana Shota and Sumbadze, Tsiuri Mikhail and Kordzaia, Mtvarisa Emzar (2025) Study of the anesthetic activity of Novocaine-containing metal complexes. World Journal of Advanced Research and Reviews, 26 (3). pp. 1753-1763. ISSN 2581-9615

The study of the biological activity of metal coordination compounds is a crucial area of research in chemistry, pharmacochemistry, and medicine. The ability of metal complexes to influence biological systems has led to their exploration in various therapeutic contexts. We have previously studied the complexes of the local anesthetics at various times. Additionally, other researchers have conducted studies on their structure and coordination properties. Some of them have a biological activity, but almost nothing is known about the biological activity of novocaine-containing compounds. Based on the above, the aim of our work is to study the local anesthetic activity of the novocaine-containing metal complexes. In particular, complex compounds, designated as Nov 1 and Nov 2, were studied. For comparison, a solution of novocaine hydrochloride with an equivalent novocaine concentration was used. The experiment was conducted on male rats weighing 250-370 g. Both substances we studied have local anesthetic property. In particular, Nov 1 is superior to novocaine hydrochloride in all respects at all concentrations studied (0.25%, 0.5%, and 1%). The anesthetic effect of Nov 2 immediately after injection is lower compared to novocaine hydrochloride, after 10 minutes these values ​​equalize, and then Nov 2 prevails over novocaine hydrochloride in strength and duration of anesthesia, especially at low concentrations. The tested substances are promising as new local anesthetics.