The therapeutic effect of aqueous extract of Prosopis farcta fruit on the inflammatory response induced by carrageenan in male albino rats

Mushatet, Mustafa K. (2025) The therapeutic effect of aqueous extract of Prosopis farcta fruit on the inflammatory response induced by carrageenan in male albino rats. International Journal of Science and Research Archive, 14 (2). pp. 768-777. ISSN 2582-8185

Traditional medicine used Prosopis farcta as a dried fruit before scientists discovered the active biological components that give this fruit its pain-relieving properties. This research looked at how well a dried fruit extract of P. farcta (AEP) worked by checking for signs of inflammation in albino rats that given carrageenan (CRG) induced tissue damage in rats. There were 32 male Rattus norvegicus animals split into four equal groups. The control group got 1 ml of physiologic solution, and the CRG group got 100 μl of a carrageenan solution dissolved in 1 ml to induce inflammation. The CRG & AEP 300 group was given AEP 300 mg/kg bw an hour after being given 100 μl of the CRG solution dissolved in 1 ml. After one hour of giving 100 ml of the dissolved CRG solution in 1 ml, the CRG & AEP 400 group received AEP 400 mg/kg bw. administered all groups orally for 30 consecutive days. They found that serum levels of C-reactive protein (CRP), MDA, the ratio of CRP to albumin (CAR), and white blood cells count (WBC) increased significantly. Concurrently, glutathione peroxidase (GPx) and albumin exhibited significant reduction. CRG caused to lower plasma CRP, MDA, and CAR levels. Carrageenan also caused a drop in GPx activity and increased ESR levels. The conclusion shows that the water-based extract of Prosopis farcta fruits can help reduce the inflammatory response linked to CRG. This is supported by the fact that certain blood and plasma parameters went down in this study.