Potential lipid lowering effect of Albizia procera leaves in chronic stress induced alzheimer’s disease in animal model

Kinekar, Nilima Shyam and Mohale, Deepak Suresh and Kochar, Nitin Indarchand and Chandewar, Anil Vishwanath (2025) Potential lipid lowering effect of Albizia procera leaves in chronic stress induced alzheimer’s disease in animal model. World Journal of Biology Pharmacy and Health Sciences, 23 (1). pp. 381-389. ISSN 2582-5542

About 70% of dementia cases have been identified to be caused by Alzheimer’s disease (AD). It is a severe type of memory loss that causes problems with language, behaviour and memory. The incidence rate of sickness doubles after 65 years of age. Prolonged stress may have an impact on the body’s physiological processes. The purpose of this work was to assess the antihyperlipidemic potential of Albizia (A.) procera leaves methanolic extract (MEt) in an animal model of AD produced by chronic stress. The plant is used as an antioxidant, analgesic, antibacterial, antidiarrheal, and antidiabetic medication. Chronic restrain stress caused learning and memory impairment over the course of 84 days with the use of MWM and EPM apparatus, hence this research aims to evaluate the impact of an oral A. procera leaves MEt (200 and 400 mg/kg) on learning and memory performance over an 84-days period. The profile of blood lipids was examined. The treated rats showed a decrease in entries and time spent in the closed arm and an increase in entries and time spent in the open arm in the modified EPM apparatus and in MWM, decrease in escape latency and an increase in retention time. The results demonstrated that administering A. procera leaves MEt enhanced learning and memory and restored abnormal lipid profile and also exhibits significant mild to moderate learning and memory enhancement activity along with antihyperlipidemic potential at both doses.