Evaluate the effect of Tai Chi Chuan in lung cancer survivors by using the biomarkers

Loo, Wings Tjing Yung and Hunt, Jason James and Cheung, Mary Ngan Bing and Loo, Preston Corliss (2025) Evaluate the effect of Tai Chi Chuan in lung cancer survivors by using the biomarkers. World Journal of Biology Pharmacy and Health Sciences, 23 (1). pp. 123-131. ISSN 2582-5542

The rising prevalence of non-small cell lung cancer (NSCLC) necessitates innovative rehabilitation strategies to enhance the quality of life for survivors. This essay explores the potential of Tai Chi Chuan (TCC), a traditional Chinese exercise known for its slow, deliberate movements and mindfulness practices, as an effective intervention for cancer rehabilitation. Through a systematic literature review, we investigate the impact of TCC on various biomarkers associated with inflammation, oxidative stress, and immune function, alongside its effects on health-related quality of life (HRQOL). Evidence suggests that TCC can significantly reduce levels of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), while enhancing antioxidant enzyme activity, thereby mitigating treatment-related side effects and promoting recovery. Furthermore, TCC has shown promise in improving physical functioning, reducing cancer-related fatigue, and enhancing psychological well-being among survivors. By fostering social interactions within group settings, TCC also addresses feelings of isolation prevalent among cancer survivors. Despite the encouraging findings, the essay highlights the need for more rigorous randomized controlled trials to further elucidate the mechanisms underlying TCC's benefits. Ultimately, this review underscores the importance of integrating holistic approaches like TCC into cancer care, paving the way for personalized rehabilitation strategies that address the complex needs of NSCLC survivors. The findings contribute to a growing body of evidence advocating for non-pharmacological interventions in cancer rehabilitation, emphasizing the interplay between physical activity, psychological health, and biological markers as vital components of effective recovery pathways.