Targeting histamine signaling in inflammation and allergy: A mechanistic and therapeutic review

Majhi, Angshuman and Sinha, Archisman and Pal, Arindam and Hossain, Anuar and Dutta, Debasish and Haque, Sk Erfanul (2025) Targeting histamine signaling in inflammation and allergy: A mechanistic and therapeutic review. World Journal of Biology Pharmacy and Health Sciences, 23 (1). 046-063. ISSN 2582-5542

Histamine, which is produced from the amino acid histidine, is involved in allergic reactions because it interacts with various G protein-coupled receptors (H₁, H₂, H₃ and H₄). This study looks into the molecular actions of histamine-mediated signaling in allergy and inflammation, especially how it brings about leukocyte recruitment, regulates the flow of fluid into tissues and activates mast cells and basophils. Today, we can understand more about the origins of disease after advances in how histamine receptors vary their distribution in various cells and the series of reactions they trigger. The research also looks into new drugs designed for specific patients as well as classical therapies targeting the actions of histamine. Research on recent findings is used to highlight both the clinical use of histamine compounds and their potential future roles in allergy disorders, chronic inflammatory diseases and autoimmune diseases. The paper stresses that research into histamine plays a major role in resolving medical issues that patients face and improving their outcomes.