Radiotherapy in nephroblastoma treatment: Insights from a retrospective study

KHALFI, Samia and ALAOUI, Bilal and SADIKI, El Mehdi and HASSANI, Wissal and FARHANE, Fatima Zahra and ALAMI, Zenab and BOUHAFA, Touria (2025) Radiotherapy in nephroblastoma treatment: Insights from a retrospective study. World Journal of Advanced Research and Reviews, 26 (3). pp. 1113-1122. ISSN 2581-9615

Wilms tumor, or nephroblastoma, is the most common pediatric renal tumor and represents a therapeutic challenge due to its often advanced presentation in our Moroccan context. This retrospective study examines 31 cases treated at CHU Hassan II of Fez between January 2014 and December 2020, assessing the impact of radiotherapy in the management of this disease. Patients underwent a multimodal approach combining chemotherapy, surgery, and radiotherapy. The analysis of epidemiological, clinical, and paraclinical data highlights the key role of radiotherapy, mainly performed using 3D conformal techniques, with or without intensity modulation, in preventing local recurrences and controlling metastases. Although some treatment-related complications were observed, the results are comparable to international standards, with an encouraging overall survival rate. These findings underscore the importance of a personalized and multidisciplinary approach to nephroblastoma management