Formulation and assessment of a probiotic-infused anti-aging cream: Harnessing the synergy of prebiotics and probiotics for skin revitalization

Mallepelli, Srivani and Guthi, Sri Chaitanya and Lakshmi K, Sri and Chowdary V, Prashanth (2025) Formulation and assessment of a probiotic-infused anti-aging cream: Harnessing the synergy of prebiotics and probiotics for skin revitalization. World Journal of Biology Pharmacy and Health Sciences, 22 (3). pp. 575-583. ISSN 2582-5542

Prebiotics, comprising natural (first generation) and generally modified (second generation) strains, play a crucial role in maintaining health. The gut and skin microbes influence immune balance, and disruptions can lead to dermatological disorders. While oral probiotics show promise in treating inflammatory skin conditions, research on topical probiotics remains limited. This review explores probiotics applications in dermatology, focusing on skin microbiome composition, common disorders, and emerging formulations, including probiotic-infused textiles. Lactic acid essential in food, pharmaceuticals, and bioplastics is predominantly produced by lactic acid bacteria. Lactobacillus sporangium, a promising yet understudied species, demonstrates high yield fermentation potential. This review examines its metabolic pathways, extraction methods, and industrial significance, highlighting the need for optimization in sustainable lactic production