A hospital-based investigation into the relationship between serum uric acid levels and estimated glomerular filtration rate in patients with chronic kidney disease

Rabha, Apurba Kumar and Baruah, Swaroop Kumar and Sharma, Manjuri (2025) A hospital-based investigation into the relationship between serum uric acid levels and estimated glomerular filtration rate in patients with chronic kidney disease. World Journal of Biology Pharmacy and Health Sciences, 22 (3). pp. 519-523. ISSN 2582-5542

Background: Chronic kidney disease (CKD) includes a range of pathophysiological processes linked to impaired kidney function and a gradual reduction in glomerular filtration rate. CKD has emerged as a global public health concern, associated with heightened risks of cardiovascular complications and decreased quality of life. Elevated serum uric acid levels are frequently observed in CKD, and this study aimed to investigate the relationship between serum uric acid levels and estimated glomerular filtration rate (eGFR) in patients with CKD. Methods: Uric acid and creatinine serum levels were assessed in 151 patients at the Department of Medicine and Nephrology of Gauhati Medical College and Hospital in Guwahati. A comprehensive medical history and clinical examination were conducted, and patients underwent required diagnostic tests. Results: In this study Uric acid levels were negatively associated with eGFR. Higher the serum uric acids levels lower the GFR values. Conclusions: Serum uric acid level is negatively associated with renal function, as assessed by eGFR.