A review on phenolic compounds and their role in treatment and management of diabetes, including vanilic acid

Rajesham, V. V. and Varsha, Dadi and Swathi, Eerjala and Renu, Jagadabi and Rao, T. Rama (2025) A review on phenolic compounds and their role in treatment and management of diabetes, including vanilic acid. World Journal of Biology Pharmacy and Health Sciences, 22 (3). pp. 492-499. ISSN 2582-5542

In recent years, there has been a noticeable shift in the approach to treating diabetes mellitus (DM), with a growing interest in alternative medicines sourced from plants. Current literature indicates that phenolic compounds extracted from plants exhibit significant health benefits. This study aims to explore the contribution of plant-derived phenolic compounds in the effective treatment and management of diabetes. Data regarding plant secondary metabolites, phenolic compounds, and their implications for diabetes treatment and management. The review includes anti-diabetic research on the four primary classes of phenolic compounds. It was found that plant-derived phenolic compounds exhibit strong anti-diabetic properties. However, each class of phenolic compounds demonstrated distinct behaviors through various mechanisms. The findings suggest that phenolic compounds from natural sources show promising anti-diabetic effects. Therefore, it can be concluded that phenolic compounds derived from diverse natural sources are crucial in the treatment and management of diabetes. Vanillic acid is a naturally occurring phenolic compound with a variety of health benefits. It is found in many fruits, vegetables, and plant extracts, and it is also produced as a metabolic byproduct. Vanillic acid has antioxidant, anti-inflammatory, and antimicrobial properties. It is also used as a flavoring agent in food products and in various industries. The study aims to review on Phenolic Compounds and Their Role in Treatment and Management of Diabetes, including vanilic acid