Signaling pathways in prostate cancer progression

Okorochi, Enoch Chibuike and Okorochi, Chinenye Mary and Akinyo, Adeyinka Samson and Jegede, Olushola Olakunle and Ehidiamhen, Felix Edoiseh and Obiozor, Augustine Ifeanyi and Ogbata, Stanley Emeka and Dike, Ejike McNelson Nlemchukwu and Dike, Daniel Onyedikachi (2025) Signaling pathways in prostate cancer progression. World Journal of Biology Pharmacy and Health Sciences, 22 (3). pp. 146-156. ISSN 2582-5542

This review article explores the intricate signaling pathways involved in the development and progression of prostate cancer, a leading malignancy among men. The primary focus is on the androgen receptor signaling pathway, which is crucial for the growth of androgen-dependent tumors, and the mechanisms by which tumors develop resistance to androgen deprivation therapy. Additionally, the review examines the roles of the phosphatidylinositol 3-kinase/Akt/mTOR pathway, the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway, and receptor tyrosine kinases in promoting tumor survival and proliferation. Notably, the cross-talk between these pathways contributes to treatment resistance, complicating therapeutic strategies. The review highlights emerging research on novel therapeutic targets and personalized medicine approaches, emphasizing the need for combination therapies to enhance treatment efficacy. By elucidating the molecular mechanisms underlying prostate cancer progression, this review aims to provide insights that could inform future therapeutic developments and improve patient outcomes in advanced and treatment-resistant cases.