Proton pump inhibitor-induced suboptimal response to levothyroxine: A primary care case report

Ahmed, Ahmed YO and Shaddad, Ahmed MA (2025) Proton pump inhibitor-induced suboptimal response to levothyroxine: A primary care case report. World Journal of Advanced Research and Reviews, 26 (3). pp. 315-316. ISSN 2581-9615

Levothyroxine is commonly prescribed in primary care for hypothyroidism patients. Its absorption may be reduced significantly by concurrent medications, especially proton pump inhibitors (PPIs).[1,2] This case report represents a practical example of reduced levothyroxine efficacy due to omeprazole use and highlights key learning points for primary care clinicians.