Modeling of the excitation propagation of the human heart

ELAFF, Ihab (2025) Modeling of the excitation propagation of the human heart. World Journal of Biology Pharmacy and Health Sciences, 22 (2). pp. 512-519. ISSN 2582-5542

This study presents a computational model for simulating excitation propagation in the human heart using a Monodomain reaction-diffusion framework coupled with the Aliev-Panfilov model for the ionic reaction term. The objective is to address the Forward Problem in cardiac electrophysiology by modeling how electrical activation initiated at the conduction system propagates through the myocardium. Cellular and tissue-level dynamics are integrated using diffusion tensor imaging (DTI)-derived anisotropy and conduction network structures. Two conduction system models are evaluated, one based on trabecular muscle anatomy and another using diffusion volume (DV) metrics. Numerical simulations demonstrate activation isochrones comparable to experimental data from Durrer et al., highlighting the model's validity in capturing realistic ventricular excitation patterns. Visualization was achieved using OpenGL-based C/C++ simulations.