A review of Cassia fistula Linn potential uses in medicine and health management

Soniya, Kumari and Boora, Sanjit and Yadav, Suman and Sharma, Manisha and Miglani, Monika and Kaushik, Samander (2025) A review of Cassia fistula Linn potential uses in medicine and health management. World Journal of Biology Pharmacy and Health Sciences, 22 (2). pp. 480-508. ISSN 2582-5542

Medicinal plants harbor unexplored reservoirs of bioactive molecules with significant therapeutic potential. The present study investigates Cassia fistula L., a medium-sized deciduous tree known as "the golden shower." In Ayurvedic Medicine, it is also called a "disease killer" and has historically been employed to treat congestion and upper respiratory tract infections. It derives its name from its attractive yellow flowers and long rod-shaped seeds. Phytochemical analysis revealed a rich nutritional profile comprising fats (12%), free amino acids (1.42%), protein (12%), and carbohydrates (11.75%). The species contains diverse bioactive compounds, including glycosides, tannins, flavonoids, anthraquinone, fistulin, fistulic acids, kaempferol, bianthroquonones, β-sitosterol, hexacosanol, and lupeol. Various plant parts demonstrated distinct therapeutic properties. Leaves and bark exhibited dermatological efficacy; roots showed diuretic potential and treated tubercular glands, heart conditions, and ulcers. Fruit pulp, rich in iron and manganese, displayed mild laxative properties. Modern pharmacological studies have validated multiple therapeutic properties such as hepatoprotective, anti-cancer, anti-pyretic, anti-inflammatory, anti-microbial, anti-fertility, anti-tussive, anti-epileptic, anti-ulcer, and anti-oxidant potential. Cassia fistula is a medicinally valuable plant with a rich history of traditional applications, supported by modern pharmacological data. The plant's diverse bioactive compounds and documented therapeutic potential make it a promising candidate for the development of novel plant-based drug. Although existing studies confirm its therapeutic potential, additional standardization and clinical trials are necessary for the advancement of modern pharmaceutical applications. This comprehensive review synthesizes knowledge of Cassia fistula's therapeutic potential and provides a foundation for future pharmaceutical research.