Duke’s contributions to improving survival rates and quality of life for brain tumor patients

Madu, Chidinma and Mofiyinfoluwa, Ajibade Victoria (2025) Duke’s contributions to improving survival rates and quality of life for brain tumor patients. World Journal of Biology Pharmacy and Health Sciences, 22 (2). pp. 342-351. ISSN 2582-5542

Background: Duke University has been at the forefront of advancing treatments for brain tumor patients, significantly improving survival rates and quality of life. Through pioneering research in immunotherapy, including the development of the poliovirus-based therapy (PVSRIPO), Duke has shown promising results in combating glioblastoma. Their cutting-edge neurosurgical techniques and precision medicine approaches have enhanced treatment efficacy while minimizing side effects. Additionally, Duke’s comprehensive brain tumor center offers multidisciplinary care, integrating innovative therapies with patient-centered support. Ongoing clinical trials continue to push the boundaries of brain tumor treatment, offering hope to patients worldwide. Aim: The aim of this study is to analyze Duke’s contributions to improving survival rates and quality of life for brain tumor patients through innovative research, advanced treatment strategies, and comprehensive patient care. This includes evaluating the impact of Duke’s breakthroughs in immunotherapy, precision medicine, and neurosurgical techniques, as well as the role of its multidisciplinary approach in enhancing patient outcomes. Methods: Duke has made significant contributions to improving survival rates and quality of life for brain tumor patients through groundbreaking research and innovative treatments. Their advancements in immunotherapy, such as the poliovirus therapy for glioblastoma, have shown promising results. Duke's specialized brain tumor center offers cutting-edge surgical techniques and personalized treatment plans. They focus on holistic patient care, integrating rehabilitation and supportive therapies to enhance quality of life. Clinical trials at Duke provide access to novel therapies, giving patients new hope and improved outcomes. Plain language summary: Duke has made major strides in improving survival rates and quality of life for brain tumor patients. Through cutting-edge research, innovative therapies, and clinical trials, they have developed more effective treatments. Their patient-centered approach ensures comprehensive, compassionate care. Advanced surgical techniques and precision medicine have enhanced outcomes. Duke continues to lead in transforming brain tumor treatment and patient well-being. Result: Duke has made major strides in improving survival rates and quality of life for brain tumor patients. Through cutting-edge research, innovative therapies, and clinical trials, they have developed more effective treatments. Their patient-centered approach ensures comprehensive, compassionate care. Advanced surgical techniques and precision medicine have enhanced outcomes. Duke continues to lead in transforming brain tumor treatment and patient well-being. Duke University has been a game-changer in the world of brain tumor research, treatment, and patient care, making a real difference in survival rates and overall quality of life. With its cutting-edge clinical trials, innovative surgical methods, and groundbreaking immunotherapy strategies, Duke’s Preston Robert Tisch Brain Tumor Center has earned its reputation as a global leader in neuro-oncology. The center has been instrumental in developing targeted therapies, like the use of poliovirus-based immunotherapy for glioblastoma, which has shown great promise in improving survival rates. Plus, advancements in precision medicine, such as genomic profiling and molecular-targeted treatments have paved the way for more personalized and effective care. Duke takes a team-based approach, bringing together experts in neurosurgery, brain tumor, and supportive care to create treatment plans that maximize effectiveness while minimizing side effects. The introduction of minimally invasive surgical techniques and state-of-the-art imaging technologies has made tumor removal more precise, leading to fewer complications and quicker recoveries for patients. On top of that, Duke has been at the forefront of research into new chemotherapy delivery methods, like convection-enhanced drug delivery, which allows for direct drug administration to tumors while bypassing the blood-brain barrier. But it’s not just about medical treatments at Duke; they’re also dedicated to enhancing patients’ quality of life through rehabilitation programs, palliative care, and mental health support. Their research into cognitive rehabilitation, lifestyle changes, and survivorship programs ensures that patients receive comprehensive care that addresses both their physical and emotional needs. Moreover, Duke's impact on brain tumor research goes beyond the lab, as they actively engage in advocacy and education to raise awareness and shape healthcare policies that benefit patients around the globe.