Effect of Spirulina platensis administration on liver catalase specific activities of various ages Wistar Rats

Paramita, Reni and Mumtaz, Isya Abiyyu (2025) Effect of Spirulina platensis administration on liver catalase specific activities of various ages Wistar Rats. World Journal of Biology Pharmacy and Health Sciences, 22 (2). pp. 283-289. ISSN 2582-5542

Oxidative stress is one of the conditions that increases following an increase in age with a significant oxidative stress can be found in the liver. Spirulina platensis is a plant that has antioxidant activity that can prevent oxidative stress. Therefore, researchers will determine the effect of Spirulina platensis on catalase specific activities in rat liver tissue of various age groups. This study is an experimental study using rat liver tissue of 30 rats aged 12 weeks, 18 weeks, and 24 weeks that were given aquadest, and aged 12 weeks, 18 weeks, and 24 weeks that have been treated with Spirulina platensis administration, compared to only treated by Aquadest administration. Specific activity of the catalase of the liver will be measured using the Claiborne method. The specific activity of catalase in rat liver is the highest in rats aged 12 weeks that were given aquadest while the lowest in mice aged 24 weeks that were given Spirulina extract. A significant difference of specific activity of catalase can be seen between rats aged 24 weeks and rats aged 12 weeks and rates aged 18 weeks. Rats that were given Spirulina extract have lower specific activity of catalase than rats that were given aquadest, with a significant difference of specific activity of catalase can be seen between rats aged 18 weeks. All rats that were given Spirulina platensis extract have a lower specific activity of catalase than rats that were given aquadest, with a significant difference can be found in rats aged 18 weeks.