Overlapping autoimmune diseases: Systemic lupus erythematosus with secondary Sjögren’s syndrome

Sireesha, Vankodoth and Sushma, Gadila and Charitha, Mekala Sai and Shirisha, Boddu and Rao, T. Rama (2025) Overlapping autoimmune diseases: Systemic lupus erythematosus with secondary Sjögren’s syndrome. World Journal of Biology Pharmacy and Health Sciences, 22 (2). pp. 180-183. ISSN 2582-5542

Systemic lupus erythematosus (SLE) and Sjogren’s syndrome (SS) are two important autoimmune conditions. SLE is characterized by increased production of autoantibodies and the development of immune complexes, SLE is a highly diverse condition that can affect multiple organ systems. Its disease activity ranges from consistently mild to potentially life-threatening. Sjogren’s syndrome arises due to the buildup of lymphocytes in the exocrine glands. The most common clinical manifestations are dry mouth (xerostomia) and dry eyes (xerophthalmia), caused by the involvement of the salivary and lacrimal glands. This paper discusses the case of a 45-year-old female diagnosed with SLE along with secondary Sjogren’s syndrome & nephrotic range proteinuria, and additional comorbidities including diabetes, hypertension, and pulmonary tuberculosis. Presenting a detailed case can help healthcare professionals improve recognition of sSS in SLE patients, ensuring timely diagnosis and comprehensive management.