Multifaceted roles of herbal compounds in dyslipidemia management: Mechanistic and therapeutic perspectives of herbal medicine

Manjusha, Kante and Sree, K. Jhansy and Indhu, Macha and Fatima, Kausar and Padmaja, V. and Sumakanth, M. (2025) Multifaceted roles of herbal compounds in dyslipidemia management: Mechanistic and therapeutic perspectives of herbal medicine. World Journal of Biology Pharmacy and Health Sciences, 22 (2). 070-090. ISSN 2582-5542

Dyslipidemia, marked by abnormal lipid levels in the blood, is a significant risk factor for cardiovascular diseases. Although conventional treatments, including statins, bile acid sequestrants, and fibric acid derivatives, are widely prescribed, they are often associated with side effects, long-term use concerns and limited efficacy in certain individuals. This has spurred growing interest in alternative treatments, particularly herbal medicine to manage dyslipidemia. This project investigates the potential of various phytochemicals in regulating lipid profiles via several mechanisms such as inhibiting cholesterol absorption in enterocytes, Reducing cholesterol synthesis, Enhancing reverse cholesterol transport, Regulating hepatic lipid uptake, and Promoting cholesterol excretion in the liver. Additionally, many phytochemicals in herbal medicine exhibit other pharmacological properties including antioxidant, anti-inflammatory and cardioprotective effects. These complementary actions improve the overall management of dyslipidemia and contribute to reducing the risk of cardiovascular diseases.