Intergraded multi omics analysis identifies antiviral host factor and pathway controlling HIV infection

Mondal, Sourav and Hazra, Ahana and Ghosh, Koushik and Dey, Ishika and Bhowmick, Pratibha and Bhowmick, Mithun (2025) Intergraded multi omics analysis identifies antiviral host factor and pathway controlling HIV infection. World Journal of Biology Pharmacy and Health Sciences, 22 (1). pp. 608-623. ISSN 2582-5542

Host anti-viral factors are crucial for controlling HIV infection, but their role remains largely unknown due to bias in previous large-scale studies. HIV-1 infection remains untreatable due to unanticipated infected cells. A large amount of OMIC data and functional genomics screening have gathered in the prose and public records. Recent years have seen the publication of interacting analyzes of related OMICs data, which recognized different types of molecular networks, including HIV-human protein-protein interaction networks, gene regulatory, co-expression networks and signaling networks, and approaches for evaluating their topology and changing aspects. Important paths and proteins complex in the HIV life cycle, cellular and immunological responses to infection, viral escape from the host immune system, with processes governing various human susceptibilities to infection may all be regulated with the use of this review. The pathways and proteins identified in this study can be used to develop new anti-HIV therapeutic strategies, such as drugs that inhibit CD4+ cell infection and viral replication, effective vaccines, and "shock and kill" and "block and lock" approaches to cure latent infections.