Genetic Mutations in Prostate Cancer: Insights and Implications

Okorochi, Chinenye Mary and Akinbo, Frederick Olusegun and Eze, Gerald Ikechi and Olukoya, Kehinde Elizabeth and Okorochi, Enoch Chibuike and Obiozor, Austin Ifeanyi and Ibe, Uzochukwu Chimdindu and Iyalla, Simon Enenche and Ukachukwu, Macpherson Ifeanyi (2025) Genetic Mutations in Prostate Cancer: Insights and Implications. World Journal of Advanced Research and Reviews, 26 (2). pp. 3744-3754. ISSN 2581-9615

This review article aims to provide a comprehensive overview of genetic mutations and alterations in prostate cancer, highlighting their roles in disease development and progression. The scope of the review encompasses common genetic mutations, such as those in the PTEN and TP53 genes, as well as structural alterations like the TMPRSS2-ERG fusion. It also discusses the impact of these genetic changes on cellular functions, including cell cycle regulation and signaling pathways. Major findings indicate that genetic mutations contribute to the uncontrolled proliferation of prostate cells and influence treatment responses, emphasizing the importance of molecular profiling in guiding personalized therapy. Additionally, the review explores the significance of the tumor microenvironment and epigenetic modifications in prostate cancer progression. The insights gained from this review underscore the necessity for ongoing research into genetic alterations to improve diagnostic methods and therapeutic strategies, ultimately enhancing patient outcomes.