Navigating the complexities of calciphylaxis: case study, diagnosis, and treatment options

Abdel-ilah, Sophia and Aboudorib, Maryem and Bendaoud, Layla and Hocar, Ouafa and Amal, Said (2025) Navigating the complexities of calciphylaxis: case study, diagnosis, and treatment options. World Journal of Advanced Research and Reviews, 26 (2). pp. 3592-3595. ISSN 2581-9615

Introduction: Calciphylaxis is a rare but serious complication, primarily observed in patients with chronic kidney disease, especially those undergoing hemodialysis. It presents with painful, ulcerated, and sometimes necrotic skin lesions. The disease can lead to rapid deterioration of the general condition, and early diagnosis is essential to improve survival chances. This article reports the clinical case of a 49-year-old female patient who developed calciphylaxis on her left leg. Materials and Methods: We describe the clinical case of a patient with chronic kidney disease on hemodialysis who presented with isolated chronic ulceronecrotic skin lesions, without any other associated cutaneous or extracutaneous signs. A comprehensive blood workup and a skin biopsy were performed to support the diagnosis. Results: Blood tests revealed elevated serum calcium levels and an increased parathyroid hormone (PTH) level. The skin biopsy showed medial calcifications and signs of vascular fibrosis, thus confirming the presence of calciphylaxis. The patient also had hyperphosphatemia, a major risk factor for the disease. Conclusion: Calciphylaxis is a rare but severe condition, often associated with chronic kidney disease and biochemical imbalances such as hyperphosphatemia. Although treatments for calciphylaxis are still under development, early diagnosis is crucial for better patient management. Treatment includes phosphate reduction, optimization of hemodialysis, and the use of sodium thiosulfate. The findings of this article highlight the importance of a multidisciplinary approach in managing this complex pathology