A case-based evaluation of personalized nutraceutical therapy in PCOD management

Srinivasan, A V and Das I, Ashwathy S and Srinivas, B V and Mondal, Mousumi and Khanra, Ayan and Manochaya, S and Agarwal, Ravindra Kumar (2025) A case-based evaluation of personalized nutraceutical therapy in PCOD management. World Journal of Biology Pharmacy and Health Sciences, 22 (1). pp. 185-189. ISSN 2582-5542

Polycystic Ovary Disease (PCOD) is a complex endocrine disorder that significantly affects the reproductive and metabolic health of women. Conventional pharmacologic treatments often provide limited success in addressing underlying metabolic dysfunctions. This 12-week observational case study evaluated the effects of a personalized nutraceutical smoothie premix on three women clinically diagnosed with PCOD. The formulation integrated Ayurvedic botanicals, essential micronutrients, and functional food ingredients designed to support hormonal balance and enhance insulin sensitivity. Participants were monitored for clinical parameters, biochemical markers, and patient-reported outcomes at baseline and study completion. Notable improvements were observed in total testosterone levels (p<0.05), fasting insulin, and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Additionally, participants reported enhanced overall well-being, improved energy levels, and better menstrual regularity. These preliminary findings suggest that personalized, integrative nutraceutical interventions may offer a promising adjunctive approach to managing PCOD by targeting its metabolic and hormonal dimensions.