Septic shock secondary to complicated UTI: A clinical case report

Koyyuru, Kranthi Kiran and Surla, Poojitha and Uppe, Roshini and Adabala, Gaana Lakshmi and Nekkanti, P Krishna Rajeswari Chowdary (2025) Septic shock secondary to complicated UTI: A clinical case report. World Journal of Biology Pharmacy and Health Sciences, 22 (1). 024-027. ISSN 2582-5542

Urosepsis is a major complication of a urinary tract infection (UTI) that happens when the infection travels to the bloodstream, potentially leading to sepsis and, in severe cases, septic shock, a life-threatening illness marked by rapid heart rate and organ malfunction. If a urinary tract infection (UTI) advances to septic shock, symptoms can include a change in mental state, fever or hypothermia, very low blood pressure, extreme pain or discomfort, and decreased urine production. Pathogens involved E.coli, Klebsiella, Citrobacter species, and P.mirabilis. Epidemiology of severe sepsis in the United States is estimated to occur in 300 cases per 100,000 population. Uti is more prevalent in women, with a lifetime risk of around 60% for women and 12% for men. UTI progress by bacteria enter the urinary tract through the urethra and multiply in the bladder. If a UTI is not treated, bacteria can move to the kidneys and circulation, leading to urosepsis, a kind of sepsis that starts in the urinary tract. When the body's immune system overreacts to an infection, it can cause organ damage and extensive inflammation leads to sepsis. Septic shock is a severe form of sepsis characterized by low blood pressure, organ failure, and a high death risk. Diagnosing tests for this condition include microbiological tests like blood cultures, urine testing, biomarkers, and imaging studies. The treatment approach for this condition includes using prompt antibiotic therapy. To maintain blood pressure and organ function IV fluids are given.