Long-term covid outcomes and cardiovascular health: New pandemic after the pandemic?

Hovornyan, Anastasiia and Ilashchuk, Tetiana (2025) Long-term covid outcomes and cardiovascular health: New pandemic after the pandemic? World Journal of Biology Pharmacy and Health Sciences, 21 (3). pp. 469-478. ISSN 2582-5542

The COVID-19 pandemic has had lasting global health effects, with many survivors experiencing persistent symptoms known as long COVID. Cardiovascular complications, including myocarditis, arrhythmias, and thromboembolic events, are among the most severe. However, the pathophysiology, risk factors, and optimal management strategies remain unclear, posing significant challenges for healthcare systems. Studies estimate that 10–70% of COVID-19 survivors experience long-term symptoms, with cardiovascular manifestations among the most prevalent. Large cohort studies report increased risks of hypertension, heart failure, and major adverse cardiovascular events post-infection. Mechanisms such as viral persistence, immune dysregulation, endothelial dysfunction, and microvascular thrombosis are implicated. Retrospective and prospective analyses show an elevated incidence of myocardial infarction and stroke among COVID-19 survivors, particularly those hospitalized. Despite growing awareness, there are no standardized clinical guidelines for diagnosing or managing long COVID-related cardiovascular conditions. Long COVID presents a substantial public health burden, particularly due to its cardiovascular effects. There is an urgent need for systematic screening, long-term monitoring, and targeted interventions to mitigate risks. Future research should focus on defining diagnostic criteria, identifying at-risk populations, and developing effective treatment strategies to improve post-COVID patient outcomes.