Design, development, formulation and evaluation of hard gelatin aspirin capsule

ABARNA, P and BALA D, MITHUN and SARAL, S and VISHNU S, SIMMA and SUJITHRA, S and KUMAR T, RANJITH and PANDI V, SUGUMAR and NITHYA, K (2025) Design, development, formulation and evaluation of hard gelatin aspirin capsule. World Journal of Biology Pharmacy and Health Sciences, 21 (3). pp. 319-325. ISSN 2582-5542

Immediate-release Aspirin capsules are widely used for the treatment of pain, fever, and inflammation, and for the prevention of cardiovascular events. This study focuses on the formulation, development, and evaluation of immediate-release Aspirin capsules. The primary aim is to design a formulation that ensures rapid disintegration and dissolution, providing quick therapeutic effects. The capsules are prepared using a blend of active pharmaceutical ingredients (Aspirin) and excipients, including starch, lactose, and talc, utilizing a hand-filling method. The stability, dissolution, disintegration, and uniformity of drug content are assessed as per pharmacopeial standards, ensuring that the final product meets the required specifications for efficacy and quality. Stability studies conducted under ICH guidelines confirm that the capsules maintain their potency and integrity over time when stored under recommended conditions. The results of this study contribute to the development of a reliable, immediate-release Aspirin dosage form that provides rapid pain relief, fever reduction, and other therapeutic benefits.