Linitis Plastica and colonic obstruction: A comprehensive review of clinical challenges and outcomes

Mohtashami, Ali and Hew, Jonathan and Senthil, Vishak and Evans, Justin (2025) Linitis Plastica and colonic obstruction: A comprehensive review of clinical challenges and outcomes. World Journal of Biology Pharmacy and Health Sciences, 21 (2). pp. 446-456. ISSN 2582-5542

Background: Linitis Plastica (LP) is a rare and highly aggressive form of gastric cancer characterized by diffuse infiltration of the stomach wall, leading to thickening and fibrosis. Due to its insidious onset and lack of early-specific symptoms, LP is often diagnosed at advanced stages, resulting in poor prognosis and limited therapeutic options. This review aims to provide a comprehensive overview of the clinical features, pathophysiology, diagnosis, and treatment options for LP, with a focus on the challenges posed by its association with colonic obstruction. Methods: This review synthesizes available literature on LP, including studies on its clinical features, diagnostic approaches, treatment options, and emerging therapies. The review also examines advancements in early detection techniques, such as liquid biopsy and imaging modalities, and the role of multidisciplinary care in managing advanced disease. Results: Early detection remains a major challenge in LP, as most cases are diagnosed after the disease has progressed to advanced stages. Standard treatments, including chemotherapy and surgery, have limited efficacy in improving survival due to the tumor’s diffuse nature and early metastasis. Emerging therapies, such as targeted treatments, immunotherapy, and biomarkers, offer promising avenues for improving outcomes, but further research is needed to fully understand their role in LP management. Advancements in early detection techniques could help identify LP at earlier, more treatable stages. Multidisciplinary approaches integrating chemotherapy, surgery, and symptomatic relief are essential to improving quality of life for affected patients. Conclusions: The review concludes that future research should focus on personalized treatment strategies, including molecular profiling and immune-based therapies, to offer better treatment options for this aggressive and often fatal condition.