The role of adiponectin in lipid profile of adults with obesity: Implications for cardiovascular health

Elvita, Azmi and Desmawati, Desmawati and Lipoeto, Nur Indrawaty (2025) The role of adiponectin in lipid profile of adults with obesity: Implications for cardiovascular health. World Journal of Advanced Research and Reviews, 25 (1). pp. 1513-1521. ISSN 25819615

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Abstract

Obesity is a global health issue closely associated with metabolic disturbances, including dyslipidemia, insulin resistance, and cardiovascular diseases. Adiponectin, a hormone secreted by adipose tissue, plays a crucial role in regulating lipid and glucose metabolism, offering protective benefits against conditions such as obesity, type 2 diabetes, and cardiovascular diseases. In individuals with obesity, adiponectin levels are typically reduced, which contributes to unfavorable lipid profiles characterized by elevated triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C). This article explores how adiponectin influences lipid metabolism, with a focus on its impact on HDL-C and TG levels in obesity. Adiponectin enhances HDL-C formation through increased apo-AI production and activates lipoprotein lipase to promote triglyceride catabolism. Additionally, adiponectin's anti-inflammatory properties help mitigate the metabolic disturbances accompanying obesity. By elucidating these mechanisms, the article underscores the potential of adiponectin as a therapeutic target for managing obesity-related dyslipidemia and reducing cardiovascular risks in obese individuals.

Item Type: Article
Uncontrolled Keywords: Adiponectin; HDL; Lipid Profile; Obesity; Triglyceride
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Depositing User: Editor WJARR
Date Deposited: 10 Jul 2025 16:41
Last Modified: 10 Jul 2025 16:41
URI: https://eprint.scholarsrepository.com/id/eprint/302

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