Neurogenesis for the treatment of Alzheimer’s disease

Kamble, Anushka Anil and Lokhande, Omkar Sunil (2025) Neurogenesis for the treatment of Alzheimer’s disease. World Journal of Biology Pharmacy and Health Sciences, 21 (2). 001-007. ISSN 2582-5542

Alzheimer’s disease is a complex neurodegenerative condition marked by progressive cognitive impairment, memory deficits, and loss of neurons. Current treatment options primarily alleviate symptoms without targeting the root causes of the disease. Emerging research on adult neurogenesis, the generation of new neurons from neural stem cells has introduced innovative strategies for addressing the underlying pathology of Alzheimer’s disease. This review explores key aspects of neurogenesis, including its regulatory mechanisms, pharmacological interventions, and the role of natural products in enhancing neurogenesis. Additionally, it highlights the therapeutic potential of these approaches in mitigating Alzheimer’s disease progression. Challenges such as delivery barriers, safety concerns, and the translational gap between preclinical and clinical research are also discussed. Future studies integrating neurogenesis-based methods with existing therapies could transform Alzheimer’s disease management and improve patient outcomes.