Antidepressant potential of Agaricus Bisporus: A comprehensive study

Sinha, Tilak Kumar and Sahu, Tilotma and Nema, Rajesh Kumar (2025) Antidepressant potential of Agaricus Bisporus: A comprehensive study. World Journal of Biology Pharmacy and Health Sciences, 21 (1). pp. 604-615. ISSN 2582-5542

Many important nutrients and medicinal bioactive chemicals are thought to be possible to be found in mushrooms. Agaricus Bisporus is the most significant commercially grown mushroom worldwide and a member of the Basidiomycetes family. Rich in minerals, vitamins, lipids, fiber, proteins, and carbohydrates, this mushroom is a well-known nutritious food. Mirtazapine is a commonly prescribed antidepressant medication that is a member of the BCS Class II drug class and has high permeability and low solubility. Goal: The formulation of the gastroretentive floating tablets of mirtazapine was statistically optimized using the Box Behnken design. Materials and Procedures: Using design expert software, a polynomial model was created after the responses were examined using the three components of the three design levels. A comparison was made between three distinct independent components. Reviewing contemporary research on the nutritional and therapeutic qualities of Agaricus Bisporus is the primary aim of this research. Only findings released after 2006 have been taken into consideration due to the acceleration of mushroom research during the past 10 years. The maintenance of human health has relied heavily on the use of therapeutic substances derived from plants and fungi from ancient times. Natural products are the source of more than half of all contemporary clinical medications and are crucial to pharmaceutical industry drug research initiatives. A significant natural food and medicinal source is mushrooms. The significance of edible and wild mushrooms was recognized by traditional Aboriginal people, and these are currently being examined for their bioactivity in treating a range of illnesses. This review's objective is to provide a concise scientific explanation of the pharmacognosy, chemistry, and pharmacology of button mushrooms.