Effect of Chlorophytum borivilianum on erectile dysfunction

Sahu, Dron Kumar and Sahu, Tilotma and Wamankar, Suchita and Sahu, Gyanesh Kumar (2025) Effect of Chlorophytum borivilianum on erectile dysfunction. World Journal of Biology Pharmacy and Health Sciences, 21 (1). pp. 364-380. ISSN 2582-5542

Chlorophytum borivilianum, which is commonly referred to as Safed Musli, is a medicinal plant that is extensively acknowledged within the framework of traditional Ayurvedic medicine for its potential to promote male reproductive health, vitality, and overall vigor. As a member of the Vajikaran Rasayana category, Safed Musli provides considerable therapeutic advantages, which encompass its aphrodisiac characteristics, effects analogous to testosterone, and its capacity as an antioxidant. This review scrutinizes the mechanisms that underpin the influence of Safed Musli on critical reproductive parameters, including sperm quality, testosterone synthesis, libido, and sexual performance. The steroidal saponins present in the herb mimic the action of testosterone, thereby facilitating spermatogenesis and maintaining hormonal equilibrium, whereas its antioxidant properties mitigate oxidative stress, thereby safeguarding sperm DNA and enhancing motility. Comparative analyses with other Vajikaran Rasayana herbs, such as Asparagus racemosus (Shatavari) and Curculigo orchioides (Kali Musli), underscore the superior androgenic properties of Safed Musli, especially in relation to augmenting testosterone levels and improving sperm characteristics. Although Shatavari contributes to reproductive health by promoting hormonal balance and enhancing vitality, Kali Musli exhibits pronounced aphrodisiac properties, particularly in the enhancement of libido and erectile function. The multifaceted role of Safed Musli in addressing male infertility, hormonal dysregulation, and sexual dysfunction emphasizes its significance within both traditional and contemporary therapeutic paradigms. Subsequent research endeavors should concentrate on elucidating its bioactive constituents, optimizing dosage protocols, and conducting extensive clinical trials to validate its efficacy and safety.