Paracetamol-induced Lyell syndrome in a 3-year-old child: A case report and review of the literature

HALI, Fouzia and ABBOUR, Anass and MEFTAH, Ahlam and CHIHEB, Soumiya (2025) Paracetamol-induced Lyell syndrome in a 3-year-old child: A case report and review of the literature. International Journal of Science and Research Archive, 15 (3). pp. 1205-1208. ISSN 2582-8185

Lyell's syndrome (LS), also known as toxic epidermal necrolysis (TEN), is a rare but severe drug-induced mucocutaneous eruption that can be fatal. Although it is a well-known condition in adults, its incidence in children is considerably lower. Among the drugs associated with LS, paracetamol (acetaminophen) is infrequently implicated. We present the case of a 3-year-old male who developed LS following paracetamol administration. This case highlights the importance of early recognition, prompt treatment, and the need for heightened awareness regarding the potential for severe adverse reactions to commonly used medications in pediatric populations.