Ameliorating effect of ethanolic leaf extract of Carica papaya (PAWPAW) on the histology of the kidney of methamphetamine-induced rats

Ukwa, Agbai Johnson and Ifegwu, Njoku Oji and Mbanaso, Eberechukwu Lolly and Agim, Cosmas Sopuruchi and Akataobi, Kelechi Uzoma and Ogbonna, Bright Chimnagozim and Ekeleme, Okezie Aloy (2025) Ameliorating effect of ethanolic leaf extract of Carica papaya (PAWPAW) on the histology of the kidney of methamphetamine-induced rats. World Journal of Advanced Research and Reviews, 26 (1). pp. 3591-3600. ISSN 2581-9615

Objective: This research study was carried out to investigate the effect of ethanolic leaf extract of Carica papaya on the histology of kidney of methamphetamine-induced rats. Methodology: Twenty-five (25) male wistar rats weighing 120 g to 150 g were procured and acclimatized for two weeks, after which, they were divided into five (5) groups of five (5) rats each, and were housed in cages. The groups were designated as groups A - E. Group A served as the control group and was not induced with methamphetamine, while Groups B – E were induced. Group A received distilled water only, Groups B - E received Methamphetamine only, 100 mg/kg of body weight of ethanolic leaf extract of Carica papaya, 200 mg/kg of body weight of ethanolic leaf extract of Carica papaya, and 300 mg/kg of body weight of ethanolic extract of Carica papaya respectively for 14 days through oral route with the aid of oral gastric tube. On the 15th day, the animals were weighed and sacrificed via chloroform inhalation, and kidneys were harvested from the rats for histological study. Results: Histopathological findings showed renal tissue with mild healing with moderate fatty changes (FC), pyknotic glomeruli (PG) and tubular atrophy (TA) for animals in group A, moderate degeneration with moderate fatty changes (FC), moderate intra renal hemorrhage (IRH), and moderate renal inflammation (IRI) for animals in group B, mild healing with moderate fatty changes (FC), pyknotic glomeruli (PG) and tubular atrophy (TA) for animals in group C, mild healing with moderate fatty changes (FC), pyknotic glomeruli (PG) and infiltration of inflammatory cell (IIC) for animals in group D, and moderate healing with mild fatty changes (FC) and infiltration of inflammatory cell (IIC) for animals in group E. Conclusion: Ethanolic leaf extracts of Carica papaya have ameliorating effect on the histology on the kidney of methamphetamine-induced rats, and the ameliorating effect improves with increase in the dosages of the extract.