Mastering glycemic control in Type 1 diabetes: Revealing bacterial threats and immune defense innovations

Salman, Ahmed Sami (2025) Mastering glycemic control in Type 1 diabetes: Revealing bacterial threats and immune defense innovations. International Journal of Science and Research Archive, 15 (2). pp. 1235-1241. ISSN 2582-8185

Background: Type 1 diabetes, also known as adolescent diabetes or insulin-dependent diabetes, is a chronic condition in which the pancreas produces a small amount of insulin. Insulin is a hormone used by the body to allow sugar (glucose) into cells to produce energy. Aim of study: to study of Incidence of Bacterial Infections in T1D Patients with and Without Insulin Therapy Methodology: HbA1C test protocol, Antibiotics sensitivity test, and Statistical analysis as a method was made to get results. Results: T1D (Insulin Users) have common infections with UTI, Cellulitis, Abscess, while T1D (Non-Adherent) with Sepsis, Osteomyelitis, UTI, and Non-Diabetic Controls associated with UTI, Respiratory, Skin infections. Conclusion: the information emphasizes how crucial insulin adherence and glycemic management are to infection risks and outcomes in people with Type 1 Diabetes (T1D). Patients with HbA1c >9% have far higher infection rates (3.2 vs. 0.8 per year) and fatality rates (e.g., sepsis: 40% vs. 15% in HbA1c <7%). 38 infections per 100 patient-years are experienced by non-adherent T1D patients, including serious infections such as osteomyelitis and sepsis. Poor adherence raises the risk of systemic infections (18%), whereas proper hygiene and insulin pump use decrease skin infections (5% and 15%, respectively). T1D individuals have greater resistance to pathogens such as S. aureus and E. coli. In order to reduce infections and enhance results, it is essential to maintain HbA1c <7% and high adherence.