Hypertrophic cardiomyopathy in a patient with myxedema: Clinical case

Yoncheva, Ivaneta Dimitrova and Bachvarov, Georgi Stefanov (2025) Hypertrophic cardiomyopathy in a patient with myxedema: Clinical case. World Journal of Advanced Research and Reviews, 26 (1). pp. 1970-1974. ISSN 2581-9615

Hypothyroidism is a common endocrine disorder that primarily affects females and has both direct and indirect effects on the cardiovascular system. Hypothyroid cardiomyopathy is a rare manifestation of this disease and can present as dilated cardiomyopathy (DCM) or, less commonly, as hypertrophic cardiomyopathy (HCM), with or without asymmetric septal hypertrophy. The deficiency of thyroid hormones leads to changes in the energy metabolism of cardiomyocytes and provokes electrical instability of the myocardium. This clinical case raises questions about the assessment of the risk of sudden cardiac death (SCD) in these patients and the need for an appropriate therapeutic strategy to improve prognosis.