Combination of calcium hydroxide and ellagic acid with polyethylene glycol solvent on pH and calcium ion release

Nirwana, Intan and Rianti, Devi and Perdani, Maya Radinka Liundzira and Jannah, Luthfiah Wardatul and Hanun, Ghaitsa Auriela (2025) Combination of calcium hydroxide and ellagic acid with polyethylene glycol solvent on pH and calcium ion release. World Journal of Advanced Research and Reviews, 26 (1). pp. 1035-1039. ISSN 2581-9615

Background: Calcium hydroxide is one of the pulp capping materials that can increase the mineralization process and inhibit the growth of bacteria. This material works by dissociating into calcium ions and hydroxyl ions and causes the pH to increase locally. Calcium ions are related to the remineralization process. The hydroxyl ion is associated with antibacterial properties. Calcium hydroxide with an alkaline pH can cause inflammation and tissue necrosis that occurs when applied in the initial period. Ellagic acid is added as an anti-inflammatory and polyethylene glycol used as a solvent which can maintain the form of Ca (OH)2 paste for a long time. Purpose: This research aimed to determine the pH changes and the release of calcium ions calcium hydroxide and ellagic acid combination using polyethylene glycol as a solvent Methods: A total of 72 samples of 4 groups consisting of the control and treatment groups which were soaked in water for 1, 3 and 7 days. The pH was examined with a pH meter and calcium ions release were examined with ICP-OES test. Result The treatment group showed an increase in pH and release of calcium ions with the highest result at a ratio of 97:3. Conclusion: The combination of calcium hydroxide and ellagic acid mixed with polyethylene glycol solvent can increase the release of calcium ions and pH.