Unraveling Alzheimer's: A holistic approach to diagnosis, stages and intervention

Dasari, Rekha and Bhukya, Geethanjali and Varadammagari, Saileela and Gujjala, Anjali and Mugannagari, Prema and Pasala, Praveen Kumar and Kanala, Somasekhar Reddy and Vattikuti, Umamaheswar Rao (2025) Unraveling Alzheimer's: A holistic approach to diagnosis, stages and intervention. International Journal of Science and Research Archive, 15 (1). pp. 888-899. ISSN 2582-8185

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder requiring a multifaceted approach to treatment and prevention. Pharmacological treatments provide symptomatic relief, with cholinesterase inhibitors (donepezil, rivastigmine, galantamine) enhancing cholinergic function and memantine regulating glutamate activity. Anti-amyloid monoclonal antibodies (aducanumab, lecanemab, donanemab) target amyloid plaques, potentially slowing cognitive decline but pose risks like amyloid-related imaging abnormalities (ARIA). Emerging therapies focus on tau-targeting strategies, including immunotherapies and small-molecule inhibitors, while advances in biomarkers such as tau-PET imaging and blood-based assays enhance early diagnosis. Preventive strategies emphasize lifestyle modifications, including regular exercise, cognitive engagement, and social interactions to support brain health. A Mediterranean diet rich in antioxidants and omega-3 fatty acids benefits cognition, while managing cardiovascular health, diabetes, and obesity reduces AD risk. Quality sleep, stress reduction, and mental well-being play essential roles, along with avoiding toxins, head injuries, smoking, and excessive alcohol. Early detection through genetic awareness and cognitive assessments enables timely intervention. Although no cure exists, integrating pharmacological and preventive measures enhances patient care, improves quality of life, and supports research toward disease-modifying treatments.